874765-16-9

Basic information

• Product Name: N-3-(trifluoromethylphenyl)quinoxalin-2-ylamine
• Synonyms: N-3-(trifluoromethylphenyl)quinoxalin-2-ylamine
• CAS NO: 874765-16-9
• Molecular Weight: 289.26
• Mol File: 874765-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-3-(trifluoromethylphenyl)quinoxalin-2-ylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-3-(trifluoromethylphenyl)quinoxalin-2-ylamine(874765-16-9)
• EPA Substance Registry System: N-3-(trifluoromethylphenyl)quinoxalin-2-ylamine(874765-16-9)

Safety Data

• Hazardous Substances Data: 874765-16-9(Hazardous Substances Data)

Upstream product

• 1448-87-9 2-chloroquinoxaline 
• 98-16-8 3-trifluoromethylaniline 

Relevant articles and documents

Microwave-assisted synthesis of quinoline, isoquinoline, quinoxaline and quinazoline derivatives as CB2 receptor agonists

Quinoline, isoquinoline, quinoxaline, and quinazoline derivatives were synthesized using microwave-assisted synthesis and their CB1/CB2 receptor activities were determined using the [35S]GTPγS binding assay. Most of the prepared quinoline, isoquinoline, and quinoxalinyl phenyl amines showed low-potency partial CB2 receptor agonists activity. The most potent CB2 ligand was the 4-morpholinylmethanone derivative (compound 40e) (-log EC 50 = 7.8; Emax = 75%). The isoquinolin-1-yl(3- trifluoromethyl-phenyl)amine (compound 26c) was a high efficacy CB2 agonist (-log EC50 = 5.8; Emax = 128%). No significant CB1 receptor activation or inactivation was shown in these studies, except 40e, which showed weak CB1 agonist activity (CB1 -log EC50 = 5.0). These ligands serve as novel templates for the development of selective CB2 receptor agonist.