874796-48-2Relevant academic research and scientific papers
Synthesis of hexahydropyrrolo[2,3-b]indole alkaloids based on the aza-Pauson-Khand-type reaction of alkynecarbodiimides
Aburano, Daisuke,Yoshida, Tatsunori,Miyakoshi, Naoki,Mukai, Chisato
, p. 6878 - 6884 (2008/02/10)
(Chemical Equation Presented) Upon treatment with 30 mol % of Co 2(CO)8 and 30 mol % of TMTU in toluene at 70°C, benzene-bridged alkynecarbodiimides efficiently underwent a ring-closing reaction to give the pyrrolo[2,3-b]-indol-2-ones in good yields. These conditions could nearly suppress the formation of the urea derivatives, which were consistently observed when 10 mol % of Co2(CO)8 and 60 mol % of TMTU in benzene were used. The synthesis of the eight hexahydropyrrolo[2,3-b]indole alkaloids was accomplished from the resulting pyrrolo[2,3-b]indol-2-ones via the introduction of an angular substituent at the C3a-position by treatment with NaBH4/alkyl bromide as the crucial step.
Co2(CO)8-catalyzed intramolecular hetero-Pauson-Khand reaction of alkynecarbodiimide: Synthesis of (±)-physostigmine
Mukai, Chisato,Yoshida, Tatsunori,Sorimachi, Mao,Odani, Akira
, p. 83 - 86 (2007/10/03)
(Chemical Equation Presented) Herein we describe a novel Co 2(CO)8-catalyzed intramolecular aza-Pauson-Khand-type reaction of alkynecarbodiimide derivatives affords pyrrolo-[2,3-b]indol-2-one ring systems in reasonable yields. This i
