874804-25-8

Usage

Chemical compound

2-amino-5-fluoro-3-methylbenzoic acid

Substituents

fluoro group and a methyl group on the benzene ring

Use

intermediate in pharmaceutical industry

Applications

synthesis of medications such as anti-inflammatory, analgesic, and antipyretic drugs
Structural similarity to salicylic acid
Potential applications in organic chemistry as a building block for complex organic molecules

Upstream product

• 952479-96-8 5-fluoro-3-methyl-2-nitrobenzoic acid 
• 518070-19-4 3-fluoro-5-methylbenzoic acid 

Downstream Products

• 1415764-25-8 2-iodo-5-fluoro-3-methylbenzoic acid 
• 1415764-06-5 (4S,5S)-2-(5-fluoro-2-iodo-3-methylphenyl)-4,5-dihydro-4-methyl-5-phenyloxazole 
• 1191420-07-1 2-amino-5-fluoro-3-methyl-benzamide 

Relevant academic research and scientific papers

DIFLUOROPYRROLIDINES AS OREXIN RECEPTOR MODULATORS

The present application relates to certain difluoropyrrolidine compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.

Catalytic enantioselective α-tosyloxylation of ketones using iodoaryloxazoline catalysts: Insights on the stereoinduction process

A family of iodooxazoline catalysts was developed to promote the iodine(III)-mediated α-tosyloxylation of ketone derivatives. The α-tosyloxy ketones produced are polyvalent chiral synthons. Through this study, we have unearthed a unique mode of stereoinduction from the chiral oxazoline moiety, where the stereogenic center alpha to the oxazoline oxygen atom is significant. Computational chemistry was used to rationalize the stereoinduction process. The catalysts presented promote currently among the best levels of activity and selectivity for this transformation. Evaluation of the scope of the reaction is presented.