874822-07-8

Basic information

• Product Name: 5-Pyrimidinecarbonitrile, 4-chloro-2-[[[2-(trifluoromethoxy)phenyl]methyl]amino]-
• CAS NO: 874822-07-8
• Molecular Formula: C13H8ClF3N4O
• Molecular Weight: 328.681
• Mol File: 874822-07-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 4-chloro-2-[[[2-(trifluoromethoxy)phenyl]methyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 4-chloro-2-[[[2-(trifluoromethoxy)phenyl]methyl]amino]-(874822-07-8)
• EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 4-chloro-2-[[[2-(trifluoromethoxy)phenyl]methyl]amino]-(874822-07-8)

Safety Data

• Hazardous Substances Data: 874822-07-8(Hazardous Substances Data)

Upstream product

• 3177-24-0 2,4-dichloropyrimidine-5-carbonitrile 
• 175205-64-8 2-(trifluoromethoxy)benzylamine 

Relevant articles and documents

Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions

Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. PKCθ inhibitors have emerged as effective immunomodulative agents for

Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.