87483-18-9

Basic information

• Product Name: Carbonothioic acid, O-ethyl S-(2-hydroxycyclopentyl) ester, trans- (9CI)
• Synonyms: Carbonothioic acid, O-ethyl S-(2-hydroxycyclopentyl) ester, trans- (9CI)
• CAS NO: 87483-18-9
• Molecular Formula: C8H14O3S
• Molecular Weight: 190.25996
• Product Categories: CYCLOPENTANE
• Mol File: 87483-18-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbonothioic acid, O-ethyl S-(2-hydroxycyclopentyl) ester, trans- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonothioic acid, O-ethyl S-(2-hydroxycyclopentyl) ester, trans- (9CI)(87483-18-9)
• EPA Substance Registry System: Carbonothioic acid, O-ethyl S-(2-hydroxycyclopentyl) ester, trans- (9CI)(87483-18-9)

Safety Data

• Hazardous Substances Data: 87483-18-9(Hazardous Substances Data)

Upstream product

• 285-67-6 Cyclopentene oxide 
• 35832-93-0 ethoxy(potassiosulfanyl)methanethione 

Relevant articles and documents

Studies on the Reaction of Mitomycin C with Potassium Ethyl Monothiocarbonate under Reductive Conditions

Treatment of mitomycin C (1) with the ambident nucleophile potassium ethyl monothiocarbonate (2) under reductive conditions (sodium dithionite) at approximately neutral pH at room temperature led to the formation of equivalent amounts of trans- (17) and cis- (18) aziridine ring-opened disubstituted mitosene adducts.In both cases substitution at carbons 1 and 10 proceeded with sulfur attack.The structural identity of each product was confirmed by high-field 1H and 13C NMR spectral ananlysis as well as by chemical studies.Milder conditions (0-5 deg C) led to the isolation of both trans- (22) and cis- (23) aziridine ring-opened monosubstituted adducts.Compounds 22 and 23 were converted to the corresponding disubstituted products by treatment with additional 2 and sodium dithionite.The implications of these reactions in relation to the mode of action of mitomycin C (1) are discussed.