874888-69-4

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 24954-67-4 2-(p-nitrophenyl)ethylamine 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 

Downstream Products

• 874888-70-7 methyl-[2-(4-nitro-phenyl)-ethyl]-(tetrahydro-pyran-4-yl)-amine 
• 874888-72-9 3,4-dichloro-N-(4-{2-[methyl-(tetrahydro-pyran-4-yl)-amino]-ethyl}-phenyl)-benzamide 
• 874888-71-8 [2-(4-amino-phenyl)-ethyl]-methyl-(tetrahydro-pyran-4-yl)-amine 

Relevant academic research and scientific papers

Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

A number of compounds bearing a quaternary ammonium moiety were found to be antagonists with nanomolar binding affinity for the chemokine receptor-2. The structure-activity relationships in the series are described herein along with some detailed characte

QUATERNARY SALT CCR2 ANTAGONISTS

Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.

Quaternary salt CCR2 antagonists

Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.