874900-01-3

Basic information

• Product Name: Acetamide, N-[5-[[4-(methylthio)phenyl]methyl]-4-[(1Z)-2-(4-nitrophenyl)ethenyl]-2-thi azolyl]-
• CAS NO: 874900-01-3
• Molecular Formula: C21H19N3O3S2
• Molecular Weight: 425.532
• Mol File: 874900-01-3.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[5-[[4-(methylthio)phenyl]methyl]-4-[(1Z)-2-(4-nitrophenyl)ethenyl]-2-thi azolyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[5-[[4-(methylthio)phenyl]methyl]-4-[(1Z)-2-(4-nitrophenyl)ethenyl]-2-thi azolyl]-(874900-01-3)
• EPA Substance Registry System: Acetamide, N-[5-[[4-(methylthio)phenyl]methyl]-4-[(1Z)-2-(4-nitrophenyl)ethenyl]-2-thi azolyl]-(874900-01-3)

Safety Data

• Hazardous Substances Data: 874900-01-3(Hazardous Substances Data)

Upstream product

• 737824-51-0 N-{4-formyl-5-[4-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide 

Downstream Products

• 737824-93-0 N-{5-[4-(methylsulfinyl)benzyl]-4-[(Z)-2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}-acetamide 

Relevant articles and documents

THIAZOLE DERIVATIVES HAVING VAP-1 INHIBITORY ACTIVITY

A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification,or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS

A compound of the formula (I): R1-NH-X-Y-Z (I) wherein R1 is acyl; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond, lower alkylene or -COHN-; and Z is a groupe of the formulae (II) or (III) wherein R