874911-96-3 Usage
Uses
Used in Pharmaceutical Research:
ZK 756326 is used as a research compound for investigating the physiological role of CCR8 in HIV infection. Its ability to inhibit the binding of the CCR8 ligand I-309 (CCL1) makes it a valuable tool for understanding the mechanisms of HIV infection and potential therapeutic targets.
Used in Drug Development:
ZK 756326 is used as a lead compound in the development of new drugs targeting the CCR8 chemokine receptor. Its agonistic properties and inhibitory effects on the binding of I-309 (CCL1) provide a foundation for designing and optimizing novel therapeutic agents to combat HIV infection and related diseases.
Used in HIV Infection Studies:
ZK 756326 is used as a research tool in the study of HIV infection, particularly in understanding the role of CCR8 chemokine receptor in the disease progression. Its ability to modulate the CCR8 receptor activity can provide insights into the development of targeted therapies and interventions for HIV treatment and prevention.
Biological Activity
Selective, non-peptide CCR8 chemokine receptor agonist (IC 50 values are 1.8 and 2.6 μ M for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α 2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
Check Digit Verification of cas no
The CAS Registry Mumber 874911-96-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,9,1 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 874911-96:
(8*8)+(7*7)+(6*4)+(5*9)+(4*1)+(3*1)+(2*9)+(1*6)=213
213 % 10 = 3
So 874911-96-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H28N2O3.6ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;;;;;;/h1-8,17,24H,9-16,18H2;6*1H
