874961-92-9Relevant academic research and scientific papers
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators
Ray, Nicholas C.,Clark, Robin D.,Clark, David E.,Williams, Karen,Hickin,Crackett, Peter H.,Dyke, Hazel J.,Lockey, Peter M.,Wong, Melanie,Devos, Rene,White, Anne,Belanoff, Joseph K.
, p. 4901 - 4905 (2008/12/22)
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which e
Modified pyrimidine glucocorticoid receptor modulators
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Page/Page column 18, (2008/06/13)
The present invention provides a novel class of modified pyrimidine compounds and compositions and methods of using the compounds as glucocorticoid receptor modulators.
