87504-16-3Relevant academic research and scientific papers
Process for scavenging thiols
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, (2008/06/13)
Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at position N-2. The process is useful pharmacologically, in inhibiting certain thiol-containing enzymes such as H+/K+-ATPase (the proton pump), and industrially, in selective removal of thiol compounds from gas or liquid mixtures.
Proton pump inhibitors
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, (2008/06/13)
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula: where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is selected from a wide range, e.g. heterocyclics and carbonyl groups.
THIADIAZOLE COMPOUNDS USEFUL AS PROTON PUMP INHIBITORS
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, (2008/06/13)
Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5-alpha] benzimidazole an
ACYLIERUNG VON HETEROCYCLEN MIT KOHLENSAEUREDERIVATEN-III; SYNTHESEN VON BENZIMIDAZOLO (1,2,4)THIADIAZOLINEN
Martin, D.,Tittelbach, F.
, p. 2311 - 2314 (2007/10/02)
The addition products of benzimidazolinethione and isocyanates are easily cyclized to benzimidazolo(1,2,4)thiadiazoline systems 4 by treatment with Br2/NEt3.The thio-analogues 9 were synthesized from 2-aminophenyl thioureas and thiophosgene followe
