875050-83-2Relevant academic research and scientific papers
Efficient synthesis of quaternary α-hydroxy acids by alkylation of α-ketoamide-derived dienediolates
Newton, Rebecca,Marsden, Stephen P.
, p. 3263 - 3270 (2007/10/03)
Double deprotonation of α-ketoamides generates dienediolates, which undergo regioselective α-alkylation to yield α-substituted-α- hydroxy-β,γ-unsaturated amides. 1,2-Disubstituted alkenes are generated exclusively as the E-isomer. 1,1-Disubstituted and 1,
