875056-24-9Relevant academic research and scientific papers
Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists
Yoshino, Hitoshi,Sato, Haruhiko,Tachibana, Kazutaka,Shiraishi, Takuya,Nakamura, Mitsuaki,Ohta, Masateru,Ishikura, Nobuyuki,Nagamuta, Masahiro,Onuma, Etsuro,Nakagawa, Toshito,Arai, Shinichi,Ahn, Koo-Hyeon,Jung, Kyung-Yun,Kawata, Hiromitsu
experimental part, p. 3159 - 3168 (2010/07/10)
A series of 5,5-dimethylthiohydantoin derivatives were synthesized and evaluated for androgen receptor pure antagonistic activities for the treatment of hormone refractory prostate cancer. CH4933468 (32d) with a sulfonamide side chain not only exhibited antagonistic activity with no agonistic activity in the reporter gene assay but also inhibited the growth of bicalutamide-resistant cell lines. This compound also inhibited tumor growth of the LNCaP xenograft in mice dose-dependently.
NOVEL IMIDAZOLIDINE DERIVATIVES
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Page/Page column 39, (2010/10/19)
Compounds represented by the general formula (I); and drugs and medicinal compositions, containing the compounds: (I) wherein n is an integer of 1 to 20; Q is (II) or (III) A is cyano or the like; B is hydrogen, halogeno, or the like; X1 and X
