875099-32-4Relevant academic research and scientific papers
Synthesis and reactivity of N-hydroxy-2-aminoindoles
Belley, Michel,Sauer, Effiette,Beaudoin, Daniel,Duspara, Petar,Trimble, Laird A.,Dubé, Pascal
, p. 159 - 162 (2007/10/03)
Catalytic hydrogenation of (2-nitrophenyl)acetonitriles bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph 3P)4Pd, affords N-hydroxy-2-aminoindoles in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile.
