875119-77-0Relevant academic research and scientific papers
Novel lead structures for antimalarial farnesyltransferase inhibitors
Kettler,Sakowski,Wiesner,Ortmann,Jomaa,Schlitzer, Martin
, p. 323 - 327 (2007/10/03)
Through the combination of nitrophenylfurylacryloyl moiety which has been designed to occupy an aryl binding site of farnesyltransferase with several AA(X)-peptidomimetic substructures some novel farnesyltransferase inhibitors were obtained. Evaluation of their antimalarial activity and some initial modifications yielded a 4-benzophenone- and a sulfonamid-based novel lead for antimalarial farnesyltransferase inhibitors.
