875153-03-0Relevant academic research and scientific papers
Synthesis of novel antibacterial and antifungal quinoxaline derivatives
Chen, Shuai,Hu, Die,Sun, Nan,Tang, Xuemei,Wu, Wenneng,Xue, Wei,Zhan, Wenliang,Zhou, Qing,Zhou, Ran
, p. 2399 - 2407 (2022/02/03)
A series of quinoxaline derivatives were designed, synthesized and evaluated as antimicrobial agents against plant pathogenic bacteria and fungi. Some of these compounds exhibited significant antibacterial and antifungal activities in vitro. Compound 5k d
Tethering identifies fragment that yields potent inhibitors of human caspase-1
Fahr, Bruce T.,O'Brien, Tom,Pham, Phuongly,Waal, Nathan D.,Baskaran, Subramanian,Raimundo, Brian C.,Lam, Joni W.,Sopko, Michelle M.,Purkey, Hans E.,Romanowski, Michael J.
, p. 559 - 562 (2007/10/03)
Disulfide Tethering was applied to the active site of human caspase-1, resulting in the discovery of a novel, tricyclic molecular fragment that selectively binds in S4. This fragment was developed into a class of potent inhibitors of human caspase-1. Seve
