875153-06-3Relevant academic research and scientific papers
Tethering identifies fragment that yields potent inhibitors of human caspase-1
Fahr, Bruce T.,O'Brien, Tom,Pham, Phuongly,Waal, Nathan D.,Baskaran, Subramanian,Raimundo, Brian C.,Lam, Joni W.,Sopko, Michelle M.,Purkey, Hans E.,Romanowski, Michael J.
, p. 559 - 562 (2007/10/03)
Disulfide Tethering was applied to the active site of human caspase-1, resulting in the discovery of a novel, tricyclic molecular fragment that selectively binds in S4. This fragment was developed into a class of potent inhibitors of human caspase-1. Seve
