875296-48-3

Upstream product

• 104-94-9 4-methoxy-aniline 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Downstream Products

• 1323941-08-7 8-(3-phenylpropyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1323941-07-6 8-(2-cyclohexylethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1323941-11-2 8-(cyclohexylmethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1323941-00-9 8-(2-(dimethyl(phenyl)silyl)ethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1323941-01-0 8-(2-(triphenylsilyl)ethyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1393651-35-8 8-(4-methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1067631-81-5 8-(2-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant academic research and scientific papers

Improving C=N bond reductions with (Cyclopentadienone)iron complexes: Scope and limitations

Herein, we broaden the application scope of (cyclo-pentadienone)iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the “Kn?lker complex” (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h–1 at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.

Efficient Synthesis of Amines by Iron-Catalyzed C=N Transfer Hydrogenation and C=O Reductive Amination

Here we report the catalytic transfer hydrogenation (CTH) of non-activated imines promoted by a Fe-catalyst in the absence of Lewis acid co-catalysts. Use of the (cyclopentadienone)iron complex 1, which is much more active than the classical ‘Kn?lker complex’ 2, allowed to reduce a number of N-aryl and N-alkyl imines in very good yields using iPrOH as hydrogen source. The reaction proceeds with relatively low catalyst loading (0.5–2 mol%) and, remarkably, its scope includes also ketimines, whose reduction with a Fe-complex as the only catalyst has little precedents. Based on this methodology, we developed a one-pot CTH protocol for the reductive amination of aldehydes/ketones, which provides access to secondary amines in high yield without the need to isolate imine intermediates. (Figure presented.).

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.

C-H activation/functionalization catalyzed by simple, well-defined low-valent cobalt complexes

A facile C-H activation and functionalization of aromatic imines is presented using low-valent cobalt catalysts. Using Co(PMe3)4 as catalyst we have developed an efficient and simple protocol for the C-H/hydroarylation of alkynes wit

Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst

Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.