87530-14-1

Usage

Uses

Used in Pharmaceutical Research:
3-[(3-Amino-propyl)-Methyl-amino]-propyl-carbamic acid tert-butyl ester is used as a building block in the pharmaceutical industry for the development of new therapeutic agents targeting various diseases. Its unique structure allows for the creation of diverse bioactive compounds with potential medicinal applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-[(3-Amino-propyl)-Methyl-amino]-propyl-carbamic acid tert-butyl ester serves as an important intermediate compound, facilitating the synthesis of a wide range of complex molecules with specific functionalities.
Used in Agriculture:
3-[(3-Amino-propyl)-Methyl-amino]-propyl-carbamic acid tert-butyl ester may also find applications in the agricultural industry, potentially contributing to the development of new agrochemicals or enhancing the properties of existing ones.
Used in Materials Science:
3-[(3-AMino-propyl)-Methyl-aMino]-propyl-carbaMic acid tert-butyl ester could be utilized in materials science for the development of novel materials with specific properties, such as improved mechanical strength, thermal stability, or chemical resistance, depending on the desired application.

Upstream product

• 105-83-9 3,3'-Diamino-N-methyldipropylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 

Downstream Products

• 916728-32-0 [3-({3-[2-(3-{[3-(2-{3-[(3-tert-butoxycarbonylamino-propyl)-methyl-amino]-propylamino}-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propylamino)-3,4-dioxo-cyclobut-1-enylamino]-propyl}-methyl-amino)-propyl]-carbamic acid tert-butyl ester 
• 916728-41-1 (3-{[3-(2-ethoxy-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester 
• 916728-31-9 (3-{[3-(2-{3-[(3-tert-butoxycarbonylamino-propyl)-methyl-amino]-propylamino}-3,4-dioxo-cyclobut-1-enylamino)-propyl]-methyl-amino}-propyl)-carbamic acid tert-butyl ester 
• 916728-33-1 C₅₀H₈₆N₁₂O₁₀ 
• 916728-34-2 C₆₁H₁₀₃N₁₅O₁₂ 
• 1158186-78-7 BocHN-(+)-^BnOIPA 
• 1229609-38-4 C₁₆₈H₃₁₇N₃₁O₄₄ 
• 1229609-36-2 C₅₇H₁₀₄N₁₀O₁₄ 
• 1351959-63-1 C₇₄H₁₃₂N₁₂O₂₂ 

Relevant academic research and scientific papers

Synthesis of ferrocenylcarbodiimide as a convenient electrochemically active labeling reagent for nucleic acids

Ferrocenylcarbodiimides carrying different redox potentials, 1 and 2, were designed and synthesized as convenient electrochemically active labeling reagents for nucleic acids, which may be used as dually labeling reagents of nucleic acids like Cy3 and Cy5 dyes. These reagents could react with the imino unit of thymine or guanine base on DNA or of uracil base on RNA under a basic buffer condition to yield a labeled product quantitatively in a short period of time. The current responses of the labeled DNAs in square wave voltammetric (SWV) measurement showed a good linear correlation with the amount of the hybridized ones. DNAs labeled with the two different reagents, 1 and 2, could be detected electrochemically at different potentials after hybridization with a DNA probe-immobilized gold electrode.

Ferrocenyl naphthalene diimide can bind to DNA·RNA hetero duplex: Potential use in an electrochemical detection of mRNA expression

The novel ferrocenyl naphthalene diimide derivative 1 was synthesized by the condensation reaction between ferroceneacetic acid and terminal amino moieties of two imide substituents of naphthalene diimide. Stopped-flow analysis of the ligand 1 and DNA interaction revealed the following results: (i) the ligand binds to double stranded DNA more strongly than to single stranded DNA; (ii) the ligand does not have a bias against DNA sequence; (iii) the ligand can bind to the DNA·RNA hetero duplex more strongly than to the DNA·DNA duplex. These properties of 1 make it a suitable ligand for analysis of not only DNA but RNA. In fact, a current due to 1 was observed at 269 mV in the differential pulse voltammetric analysis of dA20-immobilized electrode in an electrolyte containing 1. The current increased markedly upon hybridization with polyU, whereas no current increase was obtained for polyA. Since the DNA·RNA hetero duplex is formed between sample RNA and DNA on the electrode, 1 may be used for the electrochemical detection of mRNA expression.

Cyclic Naphthalene Diimide Dimer with a Strengthened Ability to Stabilize Dimeric G-Quadruplex

A new type of dimeric cyclic naphthalene diimide derivatives (cNDI-dimers) carrying varied linker length were designed and synthesized to recognize dimeric G-quadruplex structures. All of the cNDI-dimers exhibited a high preference for recognizing G-quadruplex structures, and significantly enhanced the thermal stability of the dimeric G-quadruplex structure over the cNDI monomer by increasing the melting temperature by more than 23 °C, which indicated the strengthened ability of cNDI dimers for stabilizing dimeric G-quadruplex. cNDI dimers also showed a stronger ability to inhibit telomerase activity and stop telomere DNA elongation than cNDI monomer, which showed an improved anticancer potentiality for further therapeutic application.

Cyclic ferrocenylnaphthalene diimides as a probe for electrochemical telomerase assay

Novel cyclic naphthalene diimides, 8 and 12, containing ferrocene in the cyclic linker were synthesized as G-quartet (G4) specific electrochemical ligands via the reaction of 1,1′-ferrocenedipropanoic acid and the terminal amine moieties of naphthalene diimides with varying linker lengths. The redox potentials of 8 and 12 were ca. 0.2 V (vs. Ag/AgCl), and the background current in an electrolyte was successfully suppressed. Both 8 and 12 bound to TA-core, representing human telomere G4, with K = 4.4 and 38 × 105 M?1, respectively. The current response of 12 to an electrode immobilized with G4 was the highest among the acyclic derivatives, suggesting its potential application in electrochemical telomerase assays.

METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE

The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.

Methods of inhibiting and treating biofilms using glycopeptide antibiotics

The present invention is directed to methods of inhibition, delay of formation, treatment, prophylaxis and/or prevention of infections caused by bacteria that exhibit tolerance to antimicrobial agents, including slow growing, stationary-phase and biofilm

COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

The present invention provides compounds, compositions thereof, and methods of using the same.

COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES

The present invention provides compounds, compositions thereof, and methods of using the same.

A Bis(guanidinium)alcohol Attached to a Hairpin Polyamide: Synthesis, DNA Binding, and Plasmid Cleavage

Bis(guanidinium)alcohols have been designed to react with phosphodiester substrates in a fast transphosphorylation step, a quasi-intramolecular process taking place in contact ion pairs. Here the attachment of such compounds to Dervan-type hairpin polyami

Degradable self-assembling dendrons for gene delivery: Experimental and theoretical insights into the barriers to cellular uptake

This paper uses a combined experimental and theoretical approach to gain unique insight into gene delivery. We report the synthesis and investigation of a new family of second-generation dendrons with four triamine surface ligands capable of binding to DN