875303-48-3

Upstream product

• 58645-35-5 3,4-O-isopropylidene-β-D-ribopyranose 
• 875303-39-2 (4R,5R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-5-[(E)-(S)-1-(tert-butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane 
• 875303-37-0 4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-(tert-butyl-diphenyl-silanyloxy)-but-2-enoic acid tert-butyl ester 
• 875303-43-8 {(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-acetaldehyde 
• 875303-40-5 {(4R,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 875303-42-7 (4R,5R)-4-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-5-((Z)-2-methoxy-vinyl)-2,2-dimethyl-[1,3]dioxolane 
• 875303-41-6 (4S,5R)-5-[(E)-(S)-1-(tert-Butyl-diphenyl-silanyloxy)-4-(2-trimethylsilanyl-ethoxymethoxy)-but-2-enyl]-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 875303-38-1 (E)-(S)-4-[(4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-(tert-butyl-diphenyl-silanyloxy)-but-2-en-1-ol 
• 875303-36-9 (E)-(S)-4-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4-hydroxy-but-2-enoic acid tert-butyl ester 
• 875303-35-8 (E)-(S)-4-Hydroxy-4-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid tert-butyl ester 
• 875303-47-2 (R)-1-{(3aR,4S,6R,7aR)-2,2-Dimethyl-4-[(E)-3-(2-trimethylsilanyl-ethoxymethoxy)-propenyl]-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl}-ethane-1,2-diol 
• 76-83-5 trityl chloride 

Downstream Products

• 875303-52-9 {(4R,5S)-5-[(3aR,4R,6R,7aR)-6-((R)-1-Methoxymethoxy-2-trityloxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-methanol 
• 875303-51-8 (2-{(4R,5S)-5-[(3aR,4R,6R,7aR)-6-((R)-1-Methoxymethoxy-2-trityloxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethoxy}-ethyl)-trimethyl-silane 
• 875303-27-8 5-{(4S,5R)-5-[(3aR,4R,6R,7aR)-6-((R)-1-Methoxymethoxy-2-trityloxy-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethanesulfonyl}-1-phenyl-1H-tetrazole 

Relevant academic research and scientific papers

Synthesis of the skipped polyene chain and its neighboring highly oxygenated pyran ring en route to delivering the C(43)-C(67) subsector of amphidinol 3

An approach toward a total synthesis of amphidinol 3 that focuses on elaboration of the C(43)-C(67) subunit is described. The Julia-Kocienski reaction constitutes a straightforward way to unite the skipped polyolefm chain to the adjacent highly functional