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SPIPERONE N-METHYLHCL, also known as N-Methylspiperone, is a chemical compound that functions as a D2 dopamine receptor antagonist. It is an analog of spiperone and is utilized in various applications due to its unique properties.
Used in Pharmaceutical Industry:
SPIPERONE N-METHYLHCL is used as a pharmaceutical agent for its ability to block D2 dopamine receptors, which can be beneficial in the treatment of certain conditions related to dopamine dysregulation.
Used in Neuroimaging:
In the field of neuroimaging, SPIPERONE N-METHYLHCL is used as a radiotracer for dopamine receptor imaging. Specifically, the isotope 3-N-[11C]methylspiperone ([11C]NMSP) is widely employed in positron emission tomography (PET) to visualize and assess the distribution and density of D2 dopamine receptors in the brain. This application aids in the diagnosis and monitoring of neurological disorders associated with dopamine pathways, such as schizophrenia and Parkinson's disease.

87539-19-3

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87539-19-3 Usage

Biochem/physiol Actions

D2 dopamine receptor antagonist.

Check Digit Verification of cas no

The CAS Registry Mumber 87539-19-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,5,3 and 9 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87539-19:
(7*8)+(6*7)+(5*5)+(4*3)+(3*9)+(2*1)+(1*9)=173
173 % 10 = 3
So 87539-19-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H28FN3O2/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19/h2-4,6-7,9-12H,5,8,13-18H2,1H3

87539-19-3 Well-known Company Product Price

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  • Sigma

  • (S128)  N-Methylspiperone hydrochloride  solid

  • 87539-19-3

  • S128-5MG

  • 1,375.92CNY

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87539-19-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

1.2 Other means of identification

Product number -
Other names SPIPERONE N-METHYL- HCL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:87539-19-3 SDS

87539-19-3Upstream product

87539-19-3Downstream Products

87539-19-3Relevant academic research and scientific papers

Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors

Mach,Jackson,Luedtke,Ivins,Molinoff,Ehrenkaufer

, p. 423 - 430 (2007/10/02)

Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D2 and serotonin 5-HT2 receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni

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