87539-19-3 Usage
General Description
N-Methylspiperone acts as a D2?dopamine receptor antagonist. It is an analog of spiperone. The isotope 3-N-[11C]methylspiperone ([11C]NMSP) is widely used in dopamine receptor imaging in positron emission tomography (PET).
Biochem/physiol Actions
D2 dopamine receptor antagonist.
Check Digit Verification of cas no
The CAS Registry Mumber 87539-19-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,5,3 and 9 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87539-19:
(7*8)+(6*7)+(5*5)+(4*3)+(3*9)+(2*1)+(1*9)=173
173 % 10 = 3
So 87539-19-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H28FN3O2/c1-26-18-28(21-6-3-2-4-7-21)24(23(26)30)13-16-27(17-14-24)15-5-8-22(29)19-9-11-20(25)12-10-19/h2-4,6-7,9-12H,5,8,13-18H2,1H3
87539-19-3Relevant articles and documents
Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors
Mach,Jackson,Luedtke,Ivins,Molinoff,Ehrenkaufer
, p. 423 - 430 (2007/10/02)
Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D2 and serotonin 5-HT2 receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni
