875414-71-4Relevant articles and documents
INDANONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 53, (2008/06/13)
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutama
Biphenyl-indanones: Allosteric potentiators of the metabotropic glutamate subtype 2 receptor
Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Gardner, Michael F.,Cramer, Merryl,James, Joyce K.,Rowe, Blake A.,Daggett, Lorrie P.,Schaffhauser, Herve,Kamenecka, Theodore M.
, p. 4354 - 4358 (2007/10/03)
We have identified and synthesized a series of biphenyl-carboxylic acid indanones as allosteric potentiators of the metabotropic glutamate receptor 2. Structure-activity relationship studies directed toward improving the potency and the brain to plasma ra