875429-81-5Relevant academic research and scientific papers
DTPA-bisamide-based MR sensor agents for peroxidase imaging
Querol, Manuel,Chen, John W.,Weissleder, Ralph,Bogdanov Jr., Alexei
, p. 1719 - 1722 (2005)
(Chemical Equation Presented) The synthesis and some properties of two novel DTPA-bisamides are reported. These derivatives were designed as enzyme-activated contrast agents (CA) for magnetic resonance imaging. Both derivatives bear tyramido or 5-hydroxytryptamido groups that could be oligomerized in situ in the presence of peroxidase/H2O2 pair resulting in a net increase in longitudinal (R1) relaxivity.
Bis(phenylethylamide) derivatives of Gd-DTPA as potential receptor-specific MRI contrast agents
Laurent, Sophie,Parac-Vogt, Tatjana N.,Kimpe, Kristof,Thirifays, Coralie,Binnemans, Koen,Muller, Robert N.,Vander Elst, Luce
, p. 2061 - 2067 (2008/02/09)
DTPA-bis(amide) derivatives bearing phenyl, phenol or catechol groups that mimic side chains of naturally occurring amino acids, such as phenylalanine, tyrosine or dopamine, were synthesized and characterized by elemental analysis, electrospray mass spect
A paramagnetic contrast agent with myeloperoxidase-sensing properties
Querol, Manel,Chen, John W.,Bogdanov Jr., Alexei A.
, p. 1887 - 1895 (2008/09/17)
Myeloperoxidase (MPO) is an essential component of inflammatory response in norm and pathology. With an ultimate goal of non-invasive imaging of MPO we used a gadolinium-chelating bis(5-hydroxytrytamide) derivative of diethylenetetraamine pentaacetic acid (L1-Gd3+salt) as a paramagnetic sensor of enzymatic activity. We tested whether L 1-Gd3+ is active in reducing the oxidized form of myeloperoxidase, generated as a result of hydrogen peroxide reduction by the enzyme. We expected that upon activation by MPO/H2O2 L1-Gd3+ would not only oligomerise but also bind to other macromolecules present in the media and that the overall process will give rise to a net T1-weighted MRI signal increase. The Royal Society of Chemistry 2006.
