875433-92-4

Upstream product

• 22639-28-7 (R)-goniothalamin 
• 1466-88-2 2-nitrocinnamic aldehyde 
• 1443831-22-8 (2Z,5R,6E)-7-(2-nitrophenyl)hepta-2,6-diene-1,5-diol 

Downstream Products

• 875434-02-9 10-(N-α-tert-butoxycarbonyl-L-glutaminyl)aminogoniothalamin 
• 875434-03-0 (1-{2-[2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 875434-01-8 ((1S,2S)-2-Methyl-1-{2-[(E)-2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-butyl)-carbamic acid tert-butyl ester 
• 875434-00-7 (3-methyl-1-{2-[2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-butyl)-carbamic acid tert-butyl ester 
• 875433-99-1 (2-methyl-1-{2-[2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-propyl)-carbamic acid tert-butyl ester 
• 875433-98-0 (1-{2-[2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester 
• 875433-97-9 ({2-[2-(6-oxo-3,6-dihydro-2H-pyran-2-yl)-vinyl]-phenylcarbamoyl}-methyl)-carbamic acid tert-butyl ester 
• 875433-94-6 (R)-6-[(E)-2-(2-Amino-phenyl)-vinyl]-5,6-dihydro-pyran-2-one 

Relevant academic research and scientific papers

Enantiomerically pure allylboronic esters as versatile reagents in the enantioselective synthesis of dihydro-α-pyrone-containing natural products

A short and efficient enantio- and diastereoselective synthesis of different representatives from the class of dihydro-α-pyrone natural products, including both enantiomers of goniothalamin, massoia lactone, parasorbic acid, and some derivatives is presented. It is based on the application of enantiopure α-chiral allylboronic esters in allyl additions. Georg Thieme Verlag Stuttgart New York.

Semisynthesis and antitumor activities of new styryl-lactone derivatives

Nineteen new derivatives (2-20) of the naturally occurring compound, goniothalamin (1), were prepared by chemical modification and semi-synthetic methods. The antitumor activities of these derivatives and goniothalamin were evaluated in vitro against huma