875515-91-6Relevant academic research and scientific papers
Water-soluble prodrugs of the human immunodeficiency virus protease inhibitors lopinavir and ritonavir
Degoey, David A.,Grampovnik, David J.,Flosi, William J.,Marsh, Kennan C.,Wang, Xiu C.,Klein, Larry L.,McDaniel, Keith F.,Liu, Yaya,Long, Michelle A.,Kati, Warren M.,Molla, Akhteruzzaman,Kempf, Dale J.
experimental part, p. 2964 - 2970 (2010/02/28)
We studied the synthesis, cleavage rates, and oral administration of prodrugs of the HIV protease inhibitors (PIs) lopinavir and ritonavir. Phosphate esters attached directly to the central hydroxyl groups of these PIs did not demonstrate enzyme-mediated
PRODRUGS OF HIV PROTEASE INHIBITORS
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Page/Page column 77, (2010/10/19)
A compound of the formula , or is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions or inhibiting HIV protease activity and treating HIV infection are also disclosed.
