875582-75-5

Upstream product

• 153329-04-5 3-(1,3-dioxolan-2-yl)-benzonitrile 
• 24964-64-5 3-Cyanobenzaldehyde 

Downstream Products

• 875582-81-3 tert-butyl [3-(1,3-dioxolan-2-yl)benzyl]carbamate 
• 170853-04-0 t-butyl N-(3-formylbenzyl)carbamate 
• 1355069-30-5 2-{2-[3-(1,3-dioxolan-2-yl)benzylamino]-2-oxoethoxy}-N,N-dioctylacetamide 

Relevant academic research and scientific papers

Chemistry and folding of photomodulable peptides - Stilbene and thioaurone-type candidates for conformational switches

Optimized synthetic strategies for the preparation of photoswitchable molecular scaffolds based on stilbene or on thioaurone chromophores and their conformationally directing properties, as studied by computations and by NMR spectroscopy, are addressed. For the stilbene peptidomimetics 1, 2 and 3, the length of connecting linkers between the chromophore and the peptide strands was varied, resulting in photochromic dipeptidomimetics with various flexibility. Building blocks of higher rigidity, based on para-substituted thioaurone (4 and 6) and meta-substituted thioaurone chromophores (5 and 7) are shown to have a stronger conformationally directing effect. Design, synthesis, theoretical and experimental conformational analyses are presented.

Substituted isothiazolones

This invention is directed to a compound of Formula (I): and pharmaceutically acceptable forms thereof useful as inhibitors of cPLA2 and a method for preventing, treating or ameliorating a cPLA2 mediated inflammatory related disease, disorder or condition using a compound of Formula (I) and, more particularly, for preventing, treating or ameliorating a cPLA2 mediated inflammatory related disease, disorder or condition which results from the cellular secretion of TXB2 or LTB4.

Synthesis of photoswitchable hemithioindigo-based ω-amino acids and application in Boc-based peptide assembly

Efficient procedures for the preparation of the N-Boc-protected aldehydes 5a and 5b are described which are valuable precursors for the synthesis of hemithioindigo-based ω-amino acids and peptides. Georg Thieme Verlag Stuttgart.