875584-49-9

Upstream product

• 209257-75-0 (S)-6-((tert-butyldiphenylsilyloxy)methyl)piperidin-2-one 
• 875584-43-3 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-oxo-piperidine-1-carboxylic acid benzyl ester 
• 875584-44-4 phenylmethyl 2-(tert-butyldiphenylsilyloxymethyl)-6-trifluoromethanesulfonyloxy-3,4-dihydro-2H-pyridine-1-carboxylate 
• 875584-48-8 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-(2-ethoxycarbonylvinyl)-3-methylpiperidine-1-carboxylate 
• 875584-46-6 1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-3-methylpiperidine-1,2-dicarboxylate 
• 875584-47-7 phenylmethyl 6-(tert-butyldiphenylsilyloxymethyl)-2-hydroxymethyl-3-methylpiperidine-1-carboxylate 
• 875584-45-5 1-phenylmethyl 2-methyl 6-(tert-butyldiphenylsilyloxymethyl)-5,6-dihydro-4H-pyridine-1,2-dicarboxylate 

Downstream Products

• 875584-54-6 5-[4-(tert-butyldiphenylsilyloxy)but-1-enyl]-8-methyloctahydroindolizine 

Relevant academic research and scientific papers

Flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids via a Michael-type conjugate addition

The efficient and flexible syntheses of 5,8-disubstituted indolizidine poisonous-frog alkaloids is described using a highly stereoselective Michael-type conjugate addition reaction as the key step. In this work, syntheses of the 5,8-disubstituted indolizidine poisonous-frog alkaloids (-)-231C, (-)-221I and the proposed structure for (-)-193E are reported.

The enantioselective synthesis of poison-frog alkaloids (-)-203A, (-)-209B, (-)-231C, (-)-233D, and (-)-235B″

The enantioselective synthesis of indolizidines (-)-203A, (-)-209B, (-)-231C, (-)-233D, and (-)-235B″ has been achieved and the absolute stereochemistry of both indolizidines 203A and 233D was established as 5S,8R,9S. The relative stereochemistry of natur