875609-48-6Relevant academic research and scientific papers
Rapidly Adaptive All-covalent Nanoparticle Surface Engineering
Diez-Castellnou, Marta,Suo, Rongtian,Marro, Nicolas,Matthew, Saphia A. L.,Kay, Euan R.
supporting information, p. 9948 - 9953 (2021/05/27)
Emerging nanotechnologies demand the manipulation of nanoscale components with the same predictability and programmability as is taken for granted in molecular synthetic methodologies. Yet installing appropriately reactive chemical functionality on nanomaterial surfaces has previously entailed compromises in terms of reactivity scope, functionalization density, or both. Here, we introduce an idealized dynamic covalent nanoparticle building block for divergent and adaptive post-synthesis modification of colloidal nanomaterials. Acetal-protected monolayer-stabilized gold nanoparticles are prepared via operationally simple protocols and are stable to long-term storage. Tunable surface densities of reactive aldehyde functionalities are revealed on-demand, leading to a wide range of adaptive surface engineering options from one nanoscale synthon. Analytically tractable with molecular precision, interfacial reaction kinetics and dynamic surface constitutions can be probed in situ at the ensemble level. High functionalization densities combined with rapid equilibration kinetics enable environmentally adaptive surface constitutions and rapid nanoparticle property switching in response to simple chemical effectors.
Functionalized polyethyleneimine-coated nano gold particle composite material and preparation method thereof
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Paragraph 0079-0080; 0093-0094, (2021/10/02)
The invention relates to a functional polyethyleneimine coated nano-gold particle composite material and a preparation method thereof. The preparation method comprises the following steps: adding EDCand a hyperbranched polyethyleneimine solution into mPEG
Interfacial tetrazine click chemistry mediated assembly of multifunctional colloidosomes
Agasti, Sarit S.,Das Saha, Nilanjana,Jain, Priyanka,Narayana, Chandrabhas,Pahwa, Meenakshi
supporting information, p. 9534 - 9537 (2021/09/28)
We demonstrate that tetrazine ligation chemistry can be employed to cross-link and assemble gold nanoparticles at the water-oil interface to create plasmonic colloidosomes. These biocompatible colloidosomes exhibit size tunabilityviacontrollable ligation kinetics and display high encapsulation efficiency, size-selective permeability, and surface-enhanced Raman scattering (SERS)-based sensing modality.
SELF-POWERED ENZYME MICROPUMPS
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Paragraph 0039, (2017/04/12)
Drug delivery devices, sensors, and micropumps provided herein can utilize a reaction of an analyte triggered by an enzyme to drive fluid flow. In some cases, a drug delivery device can include a reservoir including a drug (e.g., insulin) and have an enzyme (e.g., glucose oxidase) positioned adjacent to said reservoir. The enzyme can catalyze a reaction of said analyte to drive a fluid flow adjacent to said reservoir to increase a release of the drug from said reservoir. A sensor for an analyte can include an enzyme bound to a surface and a flow meter to detect a flow of fluids adjacent to said surface. A self-powered enzyme micropump provided herein can provide precise control over flow rate in response to specific signals.
Regulating exocytosis of nanoparticles via host-guest chemistry
Kim, Chaekyu,Tonga, Gulen Yesilbag,Yan, Bo,Kim, Chang Soo,Kim, Sung Tae,Park, Myoung-Hwan,Zhu, Zhengjiang,Duncan, Bradley,Creran, Brian,Rotello, Vincent M.
supporting information, p. 2474 - 2479 (2015/03/04)
Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis of the nanoparticles is a key factor in the fabrication of effective nanocarriers for chemotherapeutic treatments but orthogonal control of exocytosis in the cellular environment is a major challenge. Herein, we present the first example of regulating exocytosis of gold nanoparticles (AuNPs), a model drug carrier, by using a simple host-guest supramolecular system. AuNPs featuring quaternary amine head groups were internalized into the cells through endocytosis. Subsequent in situ treatment of a complementary cucurbit[7]uril (CB[7]) to the amine head groups resulted in the AuNP-CB[7] complexation inside cells, rendering particle assembly. This complexation induced larger particle assemblies that remained sequestered in the endosomes, inhibiting exocytosis of the particles without any observed cytotoxicity. This journal is
Reversible control of nanoparticle functionalization and physicochemical properties by dynamic covalent exchange
Della Sala, Flavio,Kay, Euan R.
supporting information, p. 4187 - 4191 (2015/03/31)
Existing methods for the covalent functionalization of nanoparticles rely on kinetically controlled reactions, and largely lack the sophistication of the preeminent oligonucleotide-based noncovalent strategies. Here we report the application of dynamic covalent chemistry for the reversible modification of nanoparticle (NP) surface functionality, combining the benefits of non-biomolecular covalent chemistry with the favorable features of equilibrium processes. A homogeneous monolayer of nanoparticle-bound hydrazones can undergo quantitative dynamic covalent exchange. The pseudomolecular nature of the NP system allows for the in situ characterization of surface-bound species, and real-time tracking of the exchange reactions. Furthermore, dynamic covalent exchange offers a simple approach for reversibly switching - and subtly tuning - NP properties such as solvophilicity.
Rapid and simple preparation of remarkably stable binary nanoparticle planet-satellite assemblies
Borsley, Stefan,Flook, Sarah,Kay, Euan R.
supporting information, p. 7812 - 7815 (2015/05/13)
We demonstrate a straightforward nonbiomolecular approach for self-assembly of binary NP planet-satellite superstructures, which display remarkable colloidal and structural stability under variations in temperature, pH, ionic strength and solvent. The rea
Zwitterionic Ligands Bound to Cdse/Zns Quantum Dots Prevent Adhesion to Mammalian Cells
Landis, Ryan F.,Tang, Rui,Hou, Singyuk,Yazdani, Mahdieh,Lee, Yiwei,Rotello, Vincent M.
, p. 2302 - 2306 (2015/12/20)
Zwitterionic materials are useful tools in material science and biology as they provide high water solubility while preventing nonspecific interactions. Quantum dots (QDs) functionalized with zwitterionic and quaternary ammonium ligands were synthesized to investigate their interactions with the outer membrane of HeLa cells. Quaternary ammonium functionalized quantum dots adhered strongly to the cell surface while zwitterionic QDs had no cell adhesion. These results demonstrate that future noninteracting nanoparticles based on this design are possible.
