875628-50-5

Upstream product

• 367260-31-9 (S,S)-2-(2-tert-butoxycarbonylamino-2-cyclohexylacetyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester 
• 166196-05-0 3-amino-2-hydroxyhexanoic acid 
• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 367259-37-8 (S,S)-2-[2-cyclohexyl-2-(7-hydroxyheptanoylamino)acetyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester 
• 367259-39-0 (S,S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-diazatricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid 
• 367259-36-7 (S,S)-2-(2-cyclohexyl-2-hept-6-enoylaminoacetyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester 
• 367259-38-9 (S,S)-3-cyclohexyl-2,5-dioxo-12-oxa-1,4-diazatricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carboxylic acid methyl ester 
• 367258-43-3 (3-tert-butoxycarbonylamino-2-hydroxyhexanoylamino)acetic acid benzyl ester 
• 166196-06-1 3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid 
• 367258-42-2 2-hydroxy-3-nitrohexanoic acid 
• 875877-47-7 {3-[((3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carbonyl)-amino]-2-hydroxy-hexanoylamino}-acetic acid benzyl ester 

Downstream Products

• 875628-51-6 {3-[((3S,18S)-3-Cyclohexyl-2,5-dioxo-12-oxa-1,4-diaza-tricyclo[11.5.3.0^16,20]henicosa-13⁽²¹⁾,14,16⁽²⁰⁾-triene-18-carbonyl)-amino]-2-oxo-hexanoylamino}-acetic acid 

Relevant academic research and scientific papers

Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease

The NS3 protease of hepatitis C virus (HCV) has emerged as one of the best characterized targets for next-generation HCV therapy. The tetrapeptide 1 and pentapeptide 2 are α-ketoamide-type HCV serine protease inhibitors with modest potency. We envisioned