875654-73-2Relevant academic research and scientific papers
Mitsunobu dehydration of N-Boc neomycin B
Quader, Sabina,Boyd, Sue E.,Jenkins, Ian D.,Houston, Todd A.
, p. 36 - 37 (2006)
Recation of hexa-N-boc neomycin B with triphenylphosphine (TPP), p-nitrobenzoic acid, and diisopropyl azodicarboxylate (DIAD) in toluene, which results in the formation of an epoxide in ring IV, was analyzed. Epoxide formation was favored by the trans-dia
ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE
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Page/Page column 126, (2010/04/27)
The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.
Multisite modification of neomycin B: Combined Mitsunobu and click chemistry approach
Quader, Sabina,Boyd, Sue E.,Jenkins, Ian D.,Houston, Todd A.
, p. 1962 - 1979 (2007/10/03)
The aminoglycoside antibiotic neomycin B has been converted into several novel building blocks that can be used for the specific modification of three of the four ring systems. Under carefully controlled conditions, the Mitsunobu reaction can be used to s
