875712-82-6

Upstream product

• 875712-81-5 benzyl O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-4,6-di-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->3)-2,6-di-O-acetyl-β-D-galactopyranosyl-(1->4)-2,3,6-tri-O-acetyl-β-D-glucopyranoside 
• 2956-16-3 uridine 5'-diphospho-D-galactose 
• 1187309-96-1 GlcNAcβ1,3Galβ1,4Glcβ-OBn 
• 1445783-71-0 C₇₆H₆₀Cl₉NO₂₃ 
• 108-24-7 acetic anhydride 
• 86520-63-0 2,3,4,6-tetra-O-acetyl-α-galactopyranosyl trichloroacetimidate 

Downstream Products

• 7578-24-7 lacto-N-tetraose 

Relevant academic research and scientific papers

SYNTHESIS OF HMO CORE STRUCTURES

The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazol

A METHOD FOR OBTAINING CRYSTALLINE LACTO-N-TETRAOSE AND LACTO-N-NEOTETRAOSE PRECURSORS AND MIXTURES THEREOF

A mixture of, preferably a mixture consisting essentially of, an lacto-N-tetraose (LNT) precursor (1) and an lacto-N-neotetraose (LNnT) precursor (2), (formula 1, 2), where R is a group removable by hydrogenolysis and R3 is either a group remov

SYNTHESIS OF HMO CORE STRUCTURES

The invention relates to a method for making precursors of HMO core structures comprising a step of reacting an N-acetyllactosamine or lacto-N-biose derivative donor with a lactose or N-acetyllactosamine derivative acceptor, wherein the donor is an oxazol

DERIVATIZATION OF OLIGOSACCHARIDES

The invention relates to a method for purifying, separating and/or isolating an oligosaccharide of general formula 1 or a salt thereof (general formula 1) wherein R1 is fucosyl or H, R2 is fucosyl or H, R3 is selected from H, sialyl, N-acetyl-lactosaminyl and lacto-N-biosyl groups, wherein the N-acetyl lactosaminyl group may carry a glycosyl residue comprising one or more N-acetyl-lactosaminyl and/or one or more lacto-N-biosyl groups; each of the N-acetyl-lactosaminyl and lacto-N-biosyl groups can be substituted with one or more sialyl and/or fucosyl residue, R4 is selected from H, or sialyl and N-acetyl-lactosaminyl groups optionally substituted with a glycosyl residue comprising one or more N-acetyl-lactosaminyl and/or one or more lacto-N-biosyl groups; each of the N-acetyl-lactosaminyl and lacto-N-biosyl groups can be substituted with one or more sialyl and/or fucosyl residue, wherein at least one of the R1, R2, R3 or R4 groups differs from H, comprising the steps: a) one or more compounds of general formula 1 is/are subjected to an anomeric O-alkylation reaction in the presence of R-X to yield a mixture comprising one or more compounds of general formula 2 or salts thereof (general formula 2) wherein X is a leaving group such as halogen, alkyl- or arylsulfonyloxy, R is a group removable by hydrogenolysis, and R1, R2, R3 and R4 are as defined above, and wherein at least one of the R1, R2, R3 or R4 groups differs from H, b) the mixture comprising one or more compounds of general formula 2 obtained in step a) is subjected to chromatography and/or crystallization to give one or more individual compounds of general formula 2 each in substantially pure form, c) an individual compound of general formula 2 in substantially pure form obtained in step b) is subjected to catalytic hydrogenolysis to yield a compound of general formula 1.

Characterization and synthetic application of a novel β1,3-galactosyltransferase from Escherichia coli O55:H7

A β1,3-galactosyltransferase (WbgO) was identified in Escherichia coli O55:H7. Its function was confirmed by radioactive activity assay and structure analysis of the disaccharide synthesized with the recombinant enzyme. WbgO requires a divalent metal ion,

Chemoenzymatic synthesis of the 3-sulfated Lewisa pentasaccharide

The sulfated pentasaccharide benzyl O-(3-O-sulfo-β-d-galactopyranosyl) -(1→3)-O-[(α-l-fucopyranosyl)-(1→4)]-O-(2-acetamido-2-deoxy- β-d-glucopyranosyl)-(1→3)-O-(β-d-galactopyranosyl)-(1→4) -O-β-d-glucopyranoside sodium salt was synthesized using a chemo-e