875753-46-1Relevant academic research and scientific papers
A practical synthesis of 4′-thioribonucleosides
Yoshimura, Yuichi,Kuze, Tetsuya,Ueno, Mari,Komiya, Fumiko,Haraguchi, Kazuhiro,Tanaka, Hiromichi,Kano, Fumitaka,Yamada, Kohei,Asami, Kazuhiro,Kaneko, Nobuaki,Takahata, Hiroki
, p. 591 - 594 (2007/10/03)
A practical synthesis of 4′-thioribonucleosides starting from inexpensive l-arabinose is described. 1,4-Anhydro-2,3-O-isopropylidene-4- thioribitol, which was prepared by using a novel reductive ring-contraction reaction, was converted to the 5-O-silylated sulfoxides. The Pummerer-type thioglycosylation of the sulfoxides gave the 4′-thioribonucleosides stereoselectively.
