875769-61-2Relevant academic research and scientific papers
5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion
Palmer, Andreas Marc,Muench, Gabriela,Brehm, Christof,Zimmermann, Peter Jan,Buhr, Wilm,Feth, Martin Philipp,Simon, Wolfgang Alexander
, p. 1511 - 1530 (2008/09/18)
A series of novel 1H-pyrrolo[3,2-b]pyridines was prepared relying on a copper iodide catalyzed cyclization of 2-prop-1-ynylpyridin-3-amines. A structure-activity relationship was established focusing on the influence of the substitution pattern in position 1, 3, and 5 of the heterocycle on anti-secretory activity, lipophilicity, and pKa value. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
5-SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINES
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Page/Page column 47, (2010/10/19)
The invention relates to compounds of the formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric acid secretion inhibiting and excellent gastric and intestinal protective action properti
