875798-21-3Relevant academic research and scientific papers
2-Aminobenzimidazoles as potent Aurora kinase inhibitors
Zhong, Min,Bui, Minna,Shen, Wang,Baskaran, Subramanian,Allen, Darin A.,Elling, Robert A.,Flanagan, W. Michael,Fung, Amy D.,Hanan, Emily J.,Harris, Shannon O.,Heumann, Stacey A.,Hoch, Ute,Ivy, Sheryl N.,Jacobs, Jeffrey W.,Lam, Stuart,Lee, Heman,McDowell, Robert S.,Oslob, Johan D.,Purkey, Hans E.,Romanowski, Michael J.,Silverman, Jeffrey A.,Tangonan, Bradley T.,Taverna, Pietro,Yang, Wenjin,Yoburn, Josh C.,Yu, Chul H.,Zimmerman, Kristin M.,O'Brien, Tom,Lew, Willard
scheme or table, p. 5158 - 5161 (2010/03/31)
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which is a
Thienopyrimidines useful as Aurora kinase inhibitors
-
Page/Page column 122, (2008/06/13)
The present invention provides compounds having the formula: wherein R1, R2, X1, X2, L1, L2, Y and Z are as defined in classes and subclasess herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., Aurora), and thus are useful, for example, for the treatment of Aurora mediated diseases.
