875902-76-4

Upstream product

• 1816-88-2 2-azido-1-phenylethan-1-one 
• 6590-94-9 3,4-dichlorophenyl isothiocyanate 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Relevant academic research and scientific papers

Electrochemical desulfurative cyclization accessing oxazol-2-amine derivatives via intermolecular C?N/C?O bond formation

A practical protocol has been established to access diverse oxazol-2-amine derivatives in one step via the electrochemical desulfurative cyclization of isothiocyanates and α-amino ketones. On the basis of the cycle of in situ generation of iodine/ desulfurative cyclization/iodide anion regeneration, the reaction is performed under metal-free and external-oxidant-free electrolytic conditions to achieve the formation of intermolecular C?O and C?N bonds, providing oxazol-2-amines in moderate to excellent yields.

OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES

Compounds, pharmaceutical compositions, and methods for treating, preventing, or ameliorating symptoms associated with diseases such as diabetes, cancer, neurodegenerative diseases, and obesity are provided. The compounds and compositions inhibit protein tyrosine phosphatase enzymes, e.g., PTP-1B.