87597-23-7Relevant academic research and scientific papers
NOVEL OXADIAZOLE COMPOUNDS
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Page/Page column 145, (2011/06/26)
Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o
NOVEL OXADIAZOLE COMPOUNDS
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Page/Page column 118, (2008/12/06)
Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation o
Research on heterocyclic compounds. XVI. 2-Methylimidazo[1,2-a]pyrazine-3-carboxylic acids
Abignente,Arena,De Caprariis,et al.
, p. 79 - 85 (2007/10/02)
A group of 2-methylimidazo[1,2-a]pyrazine-3-carboxylic acids bearing various substituents on the pyrazine ring was synthesized by the reaction of a 2-aminopyrazine with ethyl 2-chloroacetoacetate; the ethyl carboxylates so obtained gave the corresponding acids by hydrolysis. The mechanism of this synthesis was discussed. Antiinflammatory and related pharmacological activities of these carboxylic acids were compared with indomethacin.
Synthesis of imidazo[1,2-a]pyrazine derivatives with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties
Sablayrolles,Cros,Milhavet,Rechenq,Chapat,Boucard,Serrano,McNeill
, p. 206 - 212 (2007/10/02)
A series of imidazo[1,2-a]pyrazine derivatives was synthesized by condensation of α-halogenocarbonyl compounds and aminopyrazines. Various compounds resulted from competitive reactions or reagent isomerization and demonstrated in vitro uterine-relaxing and in vivo antibronchospastic activities. On isolated atria, 5-bromoimidazo[1,2-a]pyrazine showed positive chronotropic and inotropic properties; the latter was associated with an increase in the cyclic AMP tissue concentration. Potentiation of the isoproterenol positive inotropic effect of 5-bromoimidazo[1,2-a]pyrazine and the lack of blockade of the 5-bromoimidazo[1,2-a]pyrazine positive inotropic effect by propranolol suggested phosphodiesterase-inhibiting properties.
