87597-64-6

Usage

InChI:InChI=1/C14H11N3O/c15-10-11-5-4-8-13(9-11)17-14(18)16-12-6-2-1-3-7-12/h1-9H,(H2,16,17,18)

Upstream product

• 103-71-9 phenyl isocyanate 
• 2237-30-1 m-cyanoaniline 
• 619-24-9 3-nitrobenzonitrile 
• 99-09-2 3-nitro-aniline 
• 100-47-0 benzonitrile 
• 16413-26-6 3-cyanophenyl isocyanate 
• 87597-57-7 3-(3-Cyano-phenyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide 
• 62-53-3 aniline 

Downstream Products

• 92438-62-5 N,N'-bis-(3-cyano-phenyl)-urea 

Relevant academic research and scientific papers

Synthesis of substituted [11C]ureas and [11C] sulphonylureas by Rh(I)-mediated carbonylation

The urea moiety is present in many biologically active compounds and thus an attractive target for 11C-labelling. To extend the scope of the rhodium(I)-mediated carbonylative cross-coupling reaction between an azide and an amine and investigate

Antitumor Imidazotetrazines. 1. Synthesis and Chemistry of 8-Carbamoyl-3-(2-chloroethyl)imidazo-1,2,3,5-tetrazin-4(3H)-one, a Novel Broad-Spectrum Antitumor Agent

Interaction of 5-diazoimidazole-4-carboxamide and alkyl and aryl isocyanates in the dark affords 8-carbamoyl-3-substituted-imidazo-1,2,3,5-tetrazin-4(3H)-ones.In cold methanol or ethanol, the 3-(2-chloroethyl) derivative 7a decomposes to afford 2-azahypoxanthine (14) and methyl and ethyl N-(2-chloroethyl)carbamates, respectively.Compound 7a has curative activity against L-1210 and P388 leukemia and may act as a prodrug modification of the acyclic triazene 5-imidazole-4-carboxamide (MCTIC), since it ring opens to form the triazene in aqueous sodium carbonate.