876-03-9

Basic information

• Product Name: 3-Aminomethylbenzoic acid hydrochloride
• Synonyms: MAMB HCL;3-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE;3-CARBOMETHOXYBENZYLAMINE HCL;AKOS BC-1869;3-(Aminomethyl)benzoicacidHClpurum;3-(Aminomethyl)benzoicacidhydrochloridepurum;3-(Aminomethyl)benzoic acid hydrochloride 95%;3-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE PURUM 98%
• CAS NO: 876-03-9
• Molecular Formula: C₈H₉NO₂*ClH
• Molecular Weight: 187.62
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 876-03-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 242-244℃
• Boiling Point: 358.3 °C at 760 mmHg
• Flash Point: 170.5 °C
• Appearance: /Solid
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• BRN: 3697656
• CAS DataBase Reference: 3-Aminomethylbenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminomethylbenzoic acid hydrochloride(876-03-9)
• EPA Substance Registry System: 3-Aminomethylbenzoic acid hydrochloride(876-03-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 876-03-9(Hazardous Substances Data)

Usage

Chemical Properties

Solid

Uses

It is used as pharmaceutical intermediate. Derivatives of benzylamine and benzamidine were found to be competitive inhibitors of the proteolytic enzymes trypsin, plasmin, and thrombin.

Upstream product

• 51779-32-9 iminodicarboxylic acid di-tert-butyl ester 
• 31719-77-4 3-chloromethylbenzoic acid 
• 89760-77-0 3-<(benzyloxycarbonyl)aminomethyl>benzoic acid 
• 905973-32-2 3-(azidomethyl)benzenecarboxylic acid 

Downstream Products

• 153381-95-4 cyclo(Ala-Arg-Gly-Asp-Mamb) 
• 153381-95-4 cyclo(D-Ala-Arg-Gly-Asp-Mamb) 
• 153346-67-9 Boc-Mamb-Ox 
• 155567-87-6 N^α-(tert-butyloxycarbonyl)-N^α-methyl-m-(aminomethyl)benzoic acid 
• 208450-88-8 3-carbomethoxybenzylidene-3-carbomethoxybenzylamine 
• 208450-86-6 di(3-methoxycarbonylphenylmethyl)amine 
• 93071-65-9 3-methoxycarbonyl benzylamine 
• 117445-22-4 3-(tert-butoxycarbonylamino-methyl)benzoic acid 

Relevant articles and documents

Catalytic Staudinger Reduction at Room Temperature

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

AMIDINOPHENYLPYRUVIC ACID DERIVATIVES

An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood coagulation factor VII.