87601-32-9

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 61-90-5 L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 7533-40-6 2-amino-4-methyl-1-pentanol 

Downstream Products

• 1258948-42-3 (3RS,5S)-3-ethoxycarbonyl-5-(2-methylpropyl)-1-toluene-p-sulphonylpyrrolidin-2-one 
• 87601-33-0 Methyl-[(R)-4-methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphinic acid ethyl ester 
• 88129-47-9 [(R)-4-Methyl-2-(toluene-4-sulfonylamino)-pentyl]-phosphonic acid diethyl ester 
• 936012-04-3 (S)-N-(1-cyano-4-methylpentan-2-yl)-4-methylbenzenesulfonamide 
• 101833-46-9 (S)-N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 20445-29-8 N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 

Relevant academic research and scientific papers

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann-L?ffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity. (Chemical Equation Presented).

CYTOCHALASAN SYNTHESIS: SYNTHESIS OF (17S,18S)-17,18-DIHYDROXY-10-(PROP-2-YL)-14-METHYL-CYTOCHALASA-6(7),13Z,19E-TRIENE-1,21-DIONE; AN ISOMER OF ASPOCHALASIN C

On heating a dilute solution of a 2:1 mixture of the (8'E)- and (8'Z)-3-(1-oxotrienyl)-Δ3-pyrrolin-2-ones (36), Diels Alder cyclization occured.The minor (8'Z)-pyrrolinone cyclized stereoselectively to give the endo adduct (39) which has the as

SYNTHESIS OF THE RACEMIC FORM OF (Z)-1,17-DIAMINOOCTADEC-9-ENE, AN ALIPHATIC DIAMINE FROM COCCINELLIDAE. DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE (+)-NATURALLY-OCCURRING ANTIPODE

The total synthesis of the title compound (1) has been achieved.Also reported is the use of lanthanide induced shifts in 1H NMR spectroscopy to assign the absolute configuration of the α-carbon atom in chiral primary α-methylalkylamines.Application of this empirical method to natural (+)-1 shows that it has the R-configuration at C-17.

PREPARATION OF OPTICALLY ACTIVE 2-AMINOALKYLPHOSPHINIC AND PHOSPHONIC ACIDS

The reaction of sodium alkylphosphinates or sodium dialkylphosphonates with tosylamino tosylates of amino alcohols derived from 1-aminoalkylcarboxylic acids gives high yields of optically active 2-tosylaminoalkylphosphinic or phosphonic esters.