876061-33-5

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 876061-13-1 2-(benzylsulfanyl)-N-(2-bromo-4,6-difluorophenyl)-N-methylacetamide 
• 876061-25-5 2-bromo-N-(2-bromo-4,6-difluorophenyl)-N-methylacetamide 
• 876061-15-3 (E)-tert-butyl 3-(2-(2-(benzylsulfanyl)-N-methylacetamido)-3,5-difluorophenyl)acrylate 

Relevant academic research and scientific papers

Solid phase approaches to N-heterocycles using a sulfur linker cleaved by SmI2

A sulfur HASC (α-hetero-atom substituted carbonyl) linker has been utilized in solid-phase approaches to oxindoles and tetrahydroquinolones. The route to oxindoles employs the first Pummerer cyclizations on solid phase, whereas the route to tetrahydroquinolones involves a microwave-assisted Heck reaction followed by a Michael cyclization. In both cases, the linker is cleaved in a traceless fashion by electron transfer from samarium(II) iodide. The routes illustrate the compatibility of the linker system with a number of reaction types and its utility for library synthesis.

Solid-phase approach to tetrahydroquinolones using a sulfur linker cleaved by SmI2

A sulfur α-heteroatom-substituted carbonyl (HASC) linker has been utilized in a solid-phase approach to tetrahydroquinolones. The route illustrates the compatibility of the linker system with palladium-catalyzed transformations and its utility for library synthesis. The linker is cleaved by electron transfer from samarium(II) iodide.