876062-71-4Relevant articles and documents
Pharmaceutical compositions of beta-lapachone and beta-lapachone analogs with improved tumor targeting potential
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Page/Page column 45, (2008/06/13)
The present invention relates to polymer-modified quinone-containing and carbonyl-containing therapeutic agents, including polymer-modified β-lapachone compounds, and methods of treating cancer by administering the polymer-modified therapeutic agents to a subject. Polymer-modification of therapeutic agents, such as β-lapachone compounds, provides effective transport of polymer-modified therapeutic agents to tumor cells or tumor tissues by exploiting the EPR effect in tumor tissues.