87607-23-6

Basic information

• Product Name: ethyl [5-amino-3-(2,3,4-trimethoxyphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate
• Synonyms: carbamic acid, N-[5-amino-1,2-dihydro-3-(2,3,4-trimethoxyphenyl)pyrido[3,4-b]pyrazin-7-yl]-, ethyl ester
• CAS NO: 87607-23-6
• Molecular Formula: C₁₉H₂₃N₅O₅
• Molecular Weight: 401.4164
• Mol File: 87607-23-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 558.5°C at 760 mmHg
• Flash Point: 291.6°C
• Density: 1.39g/cm³
• Vapor Pressure: 1.66E-12mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: ethyl [5-amino-3-(2,3,4-trimethoxyphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [5-amino-3-(2,3,4-trimethoxyphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate(87607-23-6)
• EPA Substance Registry System: ethyl [5-amino-3-(2,3,4-trimethoxyphenyl)-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate(87607-23-6)

Safety Data

• Hazardous Substances Data: 87607-23-6(Hazardous Substances Data)

Upstream product

• 135696-15-0 2-Amino-1-(2,3,4-trimethoxy-phenyl)-ethanone oxime 
• 135696-60-5 2-[2-[(E)-Hydroxyimino]-2-(2,3,4-trimethoxy-phenyl)-ethyl]-isoindole-1,3-dione 
• 135696-27-4 {6-Amino-4-[2-[(E)-hydroxyimino]-2-(2,3,4-trimethoxy-phenyl)-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester 

Relevant articles and documents

Antimitotic Agents. Alterations at the 2,3-Positions of Ethyl (5-Amino-1,2-dihydropyridopyrazin-7-yl)carbamates

The reaction of ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate (2) with α-amino ketone oximes gave 4-pyridine oximes 3, which were reductively cyclized to give a series of ethyl (1,2-dihydropyridopyrazin-7-yl)carbamates (6).In another approach, α-nitro ketones, α-oximino ketones, and α-nitro alcohols were reduced to give α-amino alcohols, which were reacted with 2 to give 4-pyridines (5).Oxidation of these alcohols with the chromium trioxide-pyridine reagent gave the corresponding ketones (4), which were also reductively cyclized to give 6.Structure-activity relationship studies indicated that alterations at the 2- and 3-positions of the pyrazine ring of 6 had a significant effect on cytotoxicity and the inhibition of mitosis in cultured lymphoid leukemia L1210 cells.Compounds that exhibited in vitro cytotoxicities at less than 1 nM showed the same level of in vivo activity, whereas the less potent compounds showed wide variations in their in vivo activity.