87614-68-4

Usage

Molecular structure

Contains an imidazole ring and a carbamide group, as well as an amino and hydrazino group

Potential use in pharmaceuticals

Presence of the imidazole ring suggests potential biological activity

Reactivity with other compounds

Presence of the amino and hydrazino groups could indicate potential reactivity with other chemical compounds

Further research required

More analysis and research needed to fully understand the properties and potential applications of this chemical

Upstream product

• 72-40-2 5-amino-1H-imidazole-4-carboxamide monohydrochloride 
• 7008-85-7 5-diazoimidazole-4-carboxamide 
• 85622-95-3 mitozolomide 

Relevant academic research and scientific papers

Antitumor Imidazotetrazines. 1. Synthesis and Chemistry of 8-Carbamoyl-3-(2-chloroethyl)imidazo-1,2,3,5-tetrazin-4(3H)-one, a Novel Broad-Spectrum Antitumor Agent

Interaction of 5-diazoimidazole-4-carboxamide and alkyl and aryl isocyanates in the dark affords 8-carbamoyl-3-substituted-imidazo-1,2,3,5-tetrazin-4(3H)-ones.In cold methanol or ethanol, the 3-(2-chloroethyl) derivative 7a decomposes to afford 2-azahypoxanthine (14) and methyl and ethyl N-(2-chloroethyl)carbamates, respectively.Compound 7a has curative activity against L-1210 and P388 leukemia and may act as a prodrug modification of the acyclic triazene 5-imidazole-4-carboxamide (MCTIC), since it ring opens to form the triazene in aqueous sodium carbonate.

Triazines and Related Products. Part 23. New Photo-products from 5-Diazoimidazole-4-carboxamide (Diazo-IC)

Photolysis of Diazo-IC in dilute aqueous solution affords products which differ according to the pH of the medium.At pH 1, or pH 7.4 - 12 the product is 2-azahypoxanthine (2): in the intervening pH range the product is 4-carbamoylimidazolium-5-olate (3).In the dark only 2-azahypoxanthine is formed.Photolysis of Diazo-IC in concentrated solution containing citric acid (1 mol equiv.) at pH 2.5 affords a marroon imidazolylazoimidazolium olate (8) and 2-azahypoxanthine.