876147-63-6 Usage
Chemical class
1-Pyrrolidinecarboxylic acid derivatives
Explanation
The compound belongs to the category of pyrrolidinecarboxylic acids, which are organic compounds containing a pyrrolidine ring and a carboxylic acid group.
Explanation
The nitrogen atom in the compound is attached to a tert-butyl ester group, which is a bulky, non-polar group that can influence the compound's stability and solubility.
Explanation
The compound contains a thiazole ring, which is a five-membered heterocyclic ring system consisting of one sulfur atom and one nitrogen atom. Thiazole rings are commonly found in pharmaceutical compounds due to their diverse biological activities.
Explanation
The compound also contains a chlorophenyl group, which is a phenyl ring substituted with a chlorine atom. Chlorophenyl groups can influence the compound's pharmacokinetic and pharmacodynamic properties.
Explanation
Due to its unique structure and various functional groups, the compound may possess different pharmacological properties, such as antimicrobial, antiviral, or anti-inflammatory effects, making it a potential candidate for drug development and pharmaceutical research.
Explanation
The compound's potential pharmacological properties suggest that it could be studied for its therapeutic applications in the treatment of a range of diseases and medical conditions, depending on its specific effects and safety profile.
Tert-butyl ester group
1,1-dimethylethyl ester
Thiazole ring
5-thiazolyl
Chlorophenyl group
4-chlorophenyl
Potential biological activity
Antimicrobial, antiviral, or anti-inflammatory effects
Therapeutic applications
Treatment of various diseases and medical conditions
Check Digit Verification of cas no
The CAS Registry Mumber 876147-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,1,4 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 876147-63:
(8*8)+(7*7)+(6*6)+(5*1)+(4*4)+(3*7)+(2*6)+(1*3)=206
206 % 10 = 6
So 876147-63-6 is a valid CAS Registry Number.
876147-63-6Relevant academic research and scientific papers
Discovery of cyclic amine-substituted benzoic acids as PPARα agonists
Nomura, Masahiro,Yumoto, Kazuhiro,Shinozaki, Takehiro,Isogai, Shigeki,Takano, Yasuo,Murakami, Koji
scheme or table, p. 334 - 338 (2012/02/15)
A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-carboxamido]piperidin-1-yl] benzoic acid (S)-4f (KRP-105) as a potent and high subtype-selective human PPARα agonist. (S)-4f showed excellent PK profile and oral administration of (S)-4f to high-fat diet dogs effectively lowered triglycerides.
NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE
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Page/Page column 67-68, (2010/11/27)
The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or - (CH2)n- (n represents 0,1 or 2) ; X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and -COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
