876147-73-8 Usage
Molecular structure
The compound has a complex molecular structure that includes a piperidinecarboxylic acid core, a 3R configuration, a thiazolylcarbonylamino group, and a tert-butyl ester functional group.
Chemical classification
It is categorized as a carboxylic acid ester.
Core component
The core component of the compound is piperidinecarboxylic acid, which is a derivative of piperidine with a carboxylic acid group.
Chlorophenyl group
The compound contains a 4-chlorophenyl group, which is a phenyl group substituted with a chlorine atom at the 4-position.
Methyl group
The compound has a 4-methyl group attached to the thiazolyl ring, which contributes to its structure and properties.
Thiazolyl group
The compound includes a 5-thiazolyl group, which is a five-membered heterocyclic ring with sulfur and nitrogen atoms.
Carbonyl groups
The compound has multiple carbonyl groups, including a thiazolylcarbonyl group and an ester carbonyl group, which contribute to its reactivity and functional properties.
Chirality
The (3R)-configuration indicates that the compound has a specific three-dimensional arrangement of its atoms, which can affect its properties and interactions with other molecules.
Industrial, pharmaceutical, and research applications
Due to its unique chemical structure, the compound may have specific properties and uses in various industries, including pharmaceuticals and research.
Ester functional group
The compound has a tert-butyl ester functional group, which can affect its reactivity, stability, and solubility in different solvents.
Check Digit Verification of cas no
The CAS Registry Mumber 876147-73-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,6,1,4 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 876147-73:
(8*8)+(7*7)+(6*6)+(5*1)+(4*4)+(3*7)+(2*7)+(1*3)=208
208 % 10 = 8
So 876147-73-8 is a valid CAS Registry Number.
876147-73-8Relevant academic research and scientific papers
Discovery of cyclic amine-substituted benzoic acids as PPARα agonists
Nomura, Masahiro,Yumoto, Kazuhiro,Shinozaki, Takehiro,Isogai, Shigeki,Takano, Yasuo,Murakami, Koji
scheme or table, p. 334 - 338 (2012/02/15)
A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-carboxamido]piperidin-1-yl] benzoic acid (S)-4f (KRP-105) as a potent and high subtype-selective human PPARα agonist. (S)-4f showed excellent PK profile and oral administration of (S)-4f to high-fat diet dogs effectively lowered triglycerides.
NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE
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Page/Page column 76, (2010/11/27)
The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or - (CH2)n- (n represents 0,1 or 2) ; X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and -COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
