876148-26-4

Basic information

• Product Name: 5-Thiazolecarboxamide, 2-(4-chlorophenyl)-4-methyl-N-(2-morpholinylmethyl)-
• CAS NO: 876148-26-4
• Molecular Formula: C16H18ClN3O2S
• Molecular Weight: 351.857
• Mol File: 876148-26-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-Thiazolecarboxamide, 2-(4-chlorophenyl)-4-methyl-N-(2-morpholinylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Thiazolecarboxamide, 2-(4-chlorophenyl)-4-methyl-N-(2-morpholinylmethyl)-(876148-26-4)
• EPA Substance Registry System: 5-Thiazolecarboxamide, 2-(4-chlorophenyl)-4-methyl-N-(2-morpholinylmethyl)-(876148-26-4)

Safety Data

• Hazardous Substances Data: 876148-26-4(Hazardous Substances Data)

Upstream product

• 54001-17-1 2-(4-chlorophenyl)-4-methyl-1,3-thiazole-5-carboxylic acid 
• 876148-25-3 N-[[4-(tert-butoxycarbonyl)morpholin-2-yl]methyl]-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide 
• 140645-53-0 2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of cyclic amine-substituted benzoic acids as PPARα agonists

A series of novel cyclic amine-substituted benzoic acid derivatives were synthesized and evaluated for their PPARα agonist activity. Strucure-activity relationship studies led to the identification of (S)-3-[3-[2-(4-chlorophenyl)-4-methylthyazole-5-carboxamido]piperidin-1-yl] benzoic acid (S)-4f (KRP-105) as a potent and high subtype-selective human PPARα agonist. (S)-4f showed excellent PK profile and oral administration of (S)-4f to high-fat diet dogs effectively lowered triglycerides.