87620-69-7

Upstream product

• 24070-51-7 β-iodopropiophenone 
• 936-59-4 3-chloropropiophenone 
• 2298-48-8 3-morpholin-4-yl-1-phenyl-propan-1-one 
• 19271-92-2 (3-hydroxyimino-3-phenyl-propyl)-trimethyl-ammonium; iodide 
• 110-91-8 morpholine 
• 1125-87-7 acrylophenone oxime 

Downstream Products

• 14397-33-2 3-phenyl-2-isoxazoline 
• 1125-87-7 acrylophenone oxime 
• 32001-48-2 4-(3-hydroxyimino-3-phenyl-propyl)-4-methyl-morpholinium; iodide 

Relevant academic research and scientific papers

Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells

A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. Although the synthesized compounds generally revealed weaker activity or greater cytotoxicity than fluoxetine, compound 10a, in which the N-methylamino group in fluoxetine was replaced by morpholine, and the trifluoromethylphenyl ring was substituted with simple oxo group, suppressed NO production dose-dependently at 10, 20 and 40 μM concentrations with less cytotoxicity than fluoxetine, and inhibited iNOS mRNA and protein expression at the same concentrations in LPS-induced BV2 cells. The results suggested that the trifluoromethylphenyl ring moiety in fluoxetine is not necessary for the suppression of NO production and that 10a has the potential as a potent inhibitor of NO production.