876278-69-2Relevant academic research and scientific papers
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme
Duan, James J.-W.,Lu, Zhonghui,Wasserman, Zelda R.,Liu, Rui-Qin,Covington, Maryanne B.,Decicco, Carl P.
, p. 2970 - 2973 (2007/10/03)
New inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered with a pyrimidine-2,4,6-trione in place of the commonly used hydroxamic acid. These non-hydroxamate TACE inhibitors were developed by incorporating a 4-(2-methyl-4-quinolin
