876296-06-9Relevant academic research and scientific papers
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor α/δ dual agonists
Kasuga, Jun-Ichi,Makishima, Makoto,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 554 - 558 (2007/10/03)
A series of phenylpropanoic acids was prepared as candidate dual agonists of peroxisome proliferator-activated receptors (PPAR) α and δ. Structure-activity relationship studies indicated that the shape of the linker moiety and the nature of the substituen
Design, synthesis, and evaluation of a novel series of α-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) α/δ dual agonists for the treatment of metabolic syndrome
Kasuga, Jun-ichi,Yamasaki, Daisuke,Araya, Yoko,Nakagawa, Aya,Makishima, Makoto,Doi, Takefumi,Hashimoto, Yuichi,Miyachi, Hiroyuki
, p. 8405 - 8414 (2008/02/05)
A series of α-alkyl-substituted phenylpropanoic acids was prepared as dual agonists of peroxisome proliferator-activated receptors alpha and delta (PPARα/δ). Structure-activity relationship studies indicated that the shape of the linking group and the sha
