876310-02-0

Basic information

• Product Name: (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
• Synonyms: (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide;(E)-N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dim
• CAS NO: 876310-02-0
• Molecular Formula: C₃₀H₂₉ClN₆O₃
• Molecular Weight: 557
• Mol File: 876310-02-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide(876310-02-0)
• EPA Substance Registry System: (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide(876310-02-0)

Safety Data

• Hazardous Substances Data: 876310-02-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide is used as a potential therapeutic agent for various medical conditions due to its complex structure and the presence of multiple functional groups. Its specific application reason would depend on the results of further research and analysis.
Used in Biochemical Research:
In the field of biochemistry, (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide may be utilized as a research tool to study the interactions between different biomolecules and its potential as a modulator of specific biological pathways.
Used in Materials Science:
(E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide could be explored for its potential applications in materials science, such as the development of new materials with unique properties or the enhancement of existing materials through chemical modifications.

Upstream product

• 3964-52-1 2-chloro 4-aminophenol 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 848133-88-0 4-chloro-6-(5-(dimethylamino)-2-oxopent-3-enyl)-7-ethoxyquinoline-3-carbonitrile 

Relevant articles and documents

Novel preparation method of epidermal growth factor receptor (EGFR) inhibitor neratinib

The invention relates to a preparation method of an epidermal growth factor receptor (EGFR) inhibitor neratinib. The method is characterized in that 6-[(E)-4-(dimethylamino)-2-butenylamido]-7-ethoxy-4-chloro-3-quinolylmethylnitrile (I) continuously reacts with 2-chloro-3-aminophenol (II) and dichloromethylpyridine hydrochloride (III) to temporarily obtain an intermediate (E)-N-{4-[3-chloro-4-hydroxyanilino]3-cyno-5-ethoxy-6-quinolyl}-4-dimethylamino-2-butenylamide (IV) in order to finally obtain neratinib. The preparation method adopts a continuous reaction process, and dichloromethylpyridine hydrochloride (III) is a catalyst in the first stage of the continuous reaction and is a reaction reagent in the second stage of the continuous reaction, so the method has the advantages of simple and easily available raw materials, high yield, mild reaction conditions, extremely small amount of a generated waste liquid, and high facilitation of industrial production of the above raw medicine.