876314-89-5Relevant academic research and scientific papers
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5′-ribofuran-uronamide moiety
Gao, Zhan-Guo,Joshi, Bhalchandra V.,Klutz, Athena M.,Kim, Soo-Kyung,Lee, Hyuk Woo,Kim, Hea Ok,Jeong, Lak Shin,Jacobson, Kenneth A.
, p. 596 - 601 (2006)
The highly selective agonists of the A3 adenosine receptor (AR), Cl-IB-MECA (2-chloro-N6-(3-iodobenzyl)-5′-N- methylcarboxamidoadenosine), and its 4′-thio analogue, were successfully converted into selective antagonists simply by app
Structure-activity relationships of 2-chloro-N6-substituted-4′-thioadenosine-5′-N,N-dialkyluronamides as human A3 adenosine receptor antagonists
Jeong, Lak Shin,Lee, Hyuk Woo,Kim, Hea Ok,Tosh, Dilip K.,Pal, Shantanu,Choi, Won Jun,Gao, Zhan-Guo,Patel, Amit R.,Williams, Wanda,Jacobson, Kenneth A.,Kim, Hee-Doo
, p. 1612 - 1616 (2008/09/19)
On the basis of potent and selective A3 adenosine receptor (AR) antagonist, 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N,N-dimethyluronamide, structure-activity relationships were studied for a series of 5′-N,N-dialkyluronamide d
